PAIN PERCEPTION FOLLOWING SUBCUTANEOUS INJECTIONS OF CITRATE-BUFFEREDAND PHOSPHATE-BUFFERED EPOETIN-ALPHA

Authors
YU AW LEUNG CB LI PKT LUI SF LAI KN
Citation
Aw. Yu et al., PAIN PERCEPTION FOLLOWING SUBCUTANEOUS INJECTIONS OF CITRATE-BUFFEREDAND PHOSPHATE-BUFFERED EPOETIN-ALPHA, International journal of artificial organs, 21(6), 1998, pp. 341-343
Citations number
9
Categorie Soggetti
Engineering, Biomedical
Journal title
International journal of artificial organs → ACNP
ISSN journal
03913988
Volume
21
Issue
6
Year of publication
1998
Pages
341 - 343
Database
ISI
SICI code
0391-3988(1998)21:6<341:PPFSIO>2.0.ZU;2-M
Abstract
Subcutaneous injection of citrate-buffered epoetin alpha (EPO-alpha) c auses pain. Substitution of citrate buffer with a phosphate buffer in the EPO-alpha resulted in a significant reduction in duration and seve rity of pain. It is possible that sodium citrate which is present in t he EPO-alpha may be the agent that causes discomfort in the patients.