A GENETIC ASSOCIATION STUDY OF THE IGF-1 GENE AND RADIOLOGICAL OSTEOARTHRITIS IN A POPULATION-BASED COHORT STUDY (THE ROTTERDAM STUDY)

Objective-A genetic association study was performed to investigate whe ther radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene. Methods-Su bjects aged 55-65 years were selected from a population-based study of which ROA at the knee, hip, spine, and hand was assessed. Genotypes w ere determined of a polymorphism in the promoter region of the IGF-I g ene. Results-The IGF-1 locus was significantly associated with the pre sence of ROA (overall adjusted OR for heterozygous subjects 1.9, 95% C I 1.2, 3.1 and for homozygous subjects 3.6, 95% CI 0.8, 16.2). Conclus ion-These results suggest that variation at the IGF-1 locus is associa ted with ROA development and may play a part in ROA pathogenesis. To c onfirm these findings replication in at population-based sample is nee ded.