THIOPENTONE AND PROPOFOL - A COMPATIBLE MIXTURE

The physical compatibility of thiopentone and propofol mixtures was in vestigated. The investigations used were macroscopic and microscopic o bservations, zeta potential and oil droplet size measurements. There w as no evidence of instability in the mixtures. The thiopentone-propofo l mixture has the potential advantage of reducing the pain on injectio n, provides synergistic interaction, does not prolong recovery when us ed for induction of anaesthesia, may reduce the incidence of convulsio ns and is cost-effective.