THE DEVELOPMENT OF SITE-SPECIFIC DRUG-DELIVERY SYSTEMS FOR PROTEIN AND PEPTIDE BIOPHARMACEUTICALS

The desire to deliver protein and peptide biopharmaceuticals convenien tly and effectively has led to intense investigation of site-specific drug-delivery systems. Despite challenges, progress towards the conven ient noninvasive delivery of proteins and peptides has been achieved t hrough specific routes of administration. In addition, the delivery of proteins and peptides to specific sites of action has been utilized t o lower the total delivered dose, to gain access to specific organs or body compartments and to concentrate a therapeutic dose at a specific site of pharmacological action.