THE IMPACT OF 2-HYBRID AND RELATED METHODS ON BIOTECHNOLOGY

Two-hybrid technology has contributed significantly to the unraveling of molecular regulatory networks by facilitating the discovery of prot ein interactions, Outgrowths of these methods are developing rapidly, including interaction mating to identify false positives and map prote in networks, two-bait systems, systems not based on transcription, and systems permitting the selection of peptide aptamers to manipulate ge ne and allele function. These advances promise to have a significant i mpact on industrial biotechnology and drug development.