DEVELOPMENT OF A CHROMATOGRAPHIC METHOD OF ANALYSIS FOR GLUCOSYL-AMINES FORMED FROM DAPSONE

Authors
PARKIN JE BODDY MR
Citation
Je. Parkin et Mr. Boddy, DEVELOPMENT OF A CHROMATOGRAPHIC METHOD OF ANALYSIS FOR GLUCOSYL-AMINES FORMED FROM DAPSONE, Journal of liquid chromatography & related technologies, 21(14), 1998, pp. 2131-2142
Citations number
7
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of liquid chromatography & related technologies → ACNP
ISSN journal
10826076
Volume
21
Issue
14
Year of publication
1998
Pages
2131 - 2142
Database
ISI
SICI code
1082-6076(1998)21:14<2131:DOACMO>2.0.ZU;2-D
Abstract
A high performance liquid chromatrographic method has been developed f or the analysis of dapsone and the five possible mono- and diglucosyla mines formed by the reaction of dapsone with glucose. The identity of these glucosylamines has been elucidated by chemical interconversion, by spectroscopic means, and by assessment of their relative abundances at equilibrium. A novel method has been developed to enable the mono- and diglucosylamines to be quantitated using dapsone as an external s tandard.