THE INFLUENCE OF BETA-CYCLODEXTRINS ON THE SOLUBILITY OF FUROSEMIDE

Furosemide (F) is practically insoluble in water (10.26 mg/100 mt). Di fferent beta-cyclodextrins (beta-CD derivatives) were applied as host to improve the solubility of furosemide as guest molecule via inclusio n complex formation. Various molar ratios of F: beta-CD derivatives (1 : 1/2, 1 : 1 and 1 :2) and different preparative methods (physical mi xing, kneading, precipitation, spray-drying and freeze-drying) were us ed. The increase in the dissolution characteristics and the solubility of furosemide depends on the type of beta-CD derivative, on the furos emide concentration in the product and on the method of preparation. T he inclusion complexes formed between the hosts acid the guest were in vestigated by XRD, IR, and H-1-NMR spectral methods.