NO ASSOCIATION OF ALPHA(1)-ANTICHYMOTRYPSIN FLANKING REGION POLYMORPHISM AND ALZHEIMER-DISEASE RISK IN EARLY-ONSET AND LATE-ONSET ALZHEIMER-DISEASE PATIENTS

The alpha(1)-antichymotrypsin (AACT)-155 allele was found elsewhere to have a significant effect on Alzheimer disease (AD) risk in individua ls with at least one APOE-4 allele, We compared AACT genotypes of 284 cases of sporadic AD and 172 controls. The frequency of the AACT-155 a llele did not differ significantly between cases and controls, either overall or when restricted to subjects with at least one APOE-LF allel e. Logistic regression controlling for age and sex failed to show an e ffect due to AACT either alone or acting with APOE. There was no evide nce of an interaction between APOE-4 and the AACT-155 allele to reduce age at onset. Thus, our data do not support an association of AACT-15 5 with risk or age at onset in AD. (C) 1998 Elsevier Science Ireland L td. All rights reserved.