Jp. Cartron et al., INSIGHTS INTO THE STRUCTURE AND FUNCTION OF MEMBRANE POLYPEPTIDES CARRYING BLOOD-GROUP ANTIGENS, Vox sanguinis, 74, 1998, pp. 29-64
In recent years, advances in biochemistry and molecular genetics have
contributed to establishing the structure of the genes and proteins fr
om most of the 23 blood group systems presently known. Current investi
gations are focusing on genetic polymorphism analysis, tissue-specific
expression, biological properties and structure-function relationship
s. On the basis of this information, the blood group antigens were ten
tatively classified into five functional categories: (i) transporters
and channels, (ii) receptors for exogenous ligands, viruses, bacteria
and parasites, (iii) adhesion molecules, (iv) enzymes and, (v) structu
ral proteins. This review will focus on selected blood groups systems
(RH, JK, FY, LU, LW, KEL and XK) which are representative of these cla
sses of molecules, in order to illustrate how these studies may bring
new information on common and variant phenotypes and for understanding
both the mechanisms of tissue specific expression and the potential f
unction of these antigens, particularly those expressed in nonerythroi
d lineage.