MELANOMA AND PREGNANCY WITH PLACENTAL METASTASES - REPORT OF A CASE

The authors report on the case of a 33-year-old white woman who develo ped melanoma during pregnancy, with widespread metastatic disease invo lving the placenta. The melanoma developed during two consecutive preg nancies and was untreated throughout the course of both. The patient d ied with widespread metastases shortly after attempted Cesarean delive ry of her second child. Histopathologic and immunohistochemical studie s were made with anti-S-100 protein and HMB45 antibodies. The authors discuss the possible influence of pregnancy on the prognosis of melano ma.