PROPOSED OPERATION OF LARGE-SCALE ISOTACHOPHORESIS

The operation of preparative isotachophoresis with either or both the leading and trailing ions replaced by the ions with the highest and lo west mobility in the feed is proposed. The advantages of this procedur e are that one does not have to search for appropriate leading and tra iling ions, and no additional chemicals need to be added and later rec overed from the separation. The familiar steady-state theory for isota chophoresis predicts that the separation will be successful if the ban ds form. Experiments with the analogous displacement chromatography sy stem were successful.