NONCOVALENT CONTROL OF SITE-SELECTIVE INCORPORATION OF THE PYRIDOXAL-PHOSPHATE COFACTOR INTO A FOLDED POLYPEPTIDE MOTIF-MIMICKING A KEY STEP IN ENZYMATIC TRANSAMINATION

Authors
ALLERT M KJELLSTRAND M BROO K NILSSON A BALTZER L
Citation
M. Allert et al., NONCOVALENT CONTROL OF SITE-SELECTIVE INCORPORATION OF THE PYRIDOXAL-PHOSPHATE COFACTOR INTO A FOLDED POLYPEPTIDE MOTIF-MIMICKING A KEY STEP IN ENZYMATIC TRANSAMINATION, Chemical communications, (15), 1998, pp. 1547-1548
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
15
Year of publication
1998
Pages
1547 - 1548
Database
ISI
SICI code
1359-7345(1998):15<1547:NCOSIO>2.0.ZU;2-Q
Abstract
The site-selective incorporation of the pyridoxal phosphate cofactor i nto a designed polypeptide motif has been achieved and shown to be con trolled by the non-covalent interactions between the phosphate group o f the cofactor and a single arginine residue on the surface of the fol ded polypeptide.