NEW SYMMETRY-BREAKING DEPROTONATION REACTIONS OF CYCLIC IMIDES USING A CHIRAL LITHIUM AMIDE BASE

Authors
ADAMS DJ SIMPKINS NS SMITH TJN
Citation
Dj. Adams et al., NEW SYMMETRY-BREAKING DEPROTONATION REACTIONS OF CYCLIC IMIDES USING A CHIRAL LITHIUM AMIDE BASE, Chemical communications, (15), 1998, pp. 1605-1606
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
15
Year of publication
1998
Pages
1605 - 1606
Database
ISI
SICI code
1359-7345(1998):15<1605:NSDROC>2.0.ZU;2-Z
Abstract
Treatment of various N-substituted succinimides, possessing additional three-, four- or five-membered ring-fusion, with a mixture of chiral lithium amide base and Me3SiCl, enables enantioselective silylation to give products in up to 95% ee.