GLYCOCONJUGATES OF AMINES - ALKYLATION OF PRIMARY AND SECONDARY-AMINES WITH N-CHLOROACETYL-BETA-GLYCOPYRANOSYLAMINES

Efficient monoalkylation of a series of primary and secondary amines w as demonstrated with the use of N-chloroacetylglycosylamines derived f rom D-glucose, D-galactose, D-mannose, N-acetyl-D-glucosamine, and lac tose. The reaction was shown to be useful for incorporation of carbohy drate residues into physiologically active compounds. Glycoconjugates of some derivatives of piperazine, 2-phenylethylamine, tryptamine, and important biogenic amines (norephedrine, octopamine, dopamine) were p repared.