COMPLEMENT RECEPTORS IN SHOCK AND TRANSPLANTATION

Over the last decade, elegant studies of the basic biologic characteri stics of inflammation and tissue injury have implicated leukocyte-medi ated vascular and tissue injury in the pathogenesis of a wide variety of immune and inflammatory clinical disorders, including allograft rej ection, adult respiratory distress syndrome, and shock. Recognition of the importance of leukocyte adherence to the endothelium in the patho genesis of these disorders, in combination with advances in cellular a nd molecular biology, have led to the development of novel therapeutic approaches to the treatment of immune and inflammatory disorders in w hich leukocytes contribute to vascular and tissue injury. Several of t hese promising new therapeutic approaches have focused on the compleme nt system. Examples of this therapeutic approach include the use of mo noclonal antibodies directed at leukocyte complement receptors and the administration of soluble complement receptors to inhibit the binding of leukocytes to the endothelium. Because of the biologic and signifi cant potential clinical importance of these advances, in this review, we focus on the complement system and complement receptor-mediated tis sue injury.