EFFECTS OF CILOSTAZOL ON LATE LUMEN LOSS AFTER PALMAZ-SCHATZ STENT IMPLANTATION

Cilostazol inhibits intimal hyperplasia after stent implantation into canine iliac arteries. To determine the antiproliferative effect of th is agent, cilostazol or aspirin was randomly given for 6 mo to 36 pati ents treated with Palmaz-Schatz stent implantation. Initial success wa s obtained in 34 patients. Repeat angiography was performed in 33 pati ents, and the complete angiographic data were obtained in 22 lesions o f the cilostazol group and in 21 lesions of the aspirin group. The ref erence diameter and minimal luminal diameter were similar in both grou ps before and immediately after stent implantation. At follow-up, mini mal luminal diameters were significantly greater in the cilostazol gro up than in the aspirin group (P < 0.001). Late loss and loss index wer e significantly smaller in the cilostazol group than in the aspirin gr oup (P < 0.001). These results suggest that cilostazol reduces angiogr aphic late lumen loss and thereby may reduce the incidence of restenos is after Palmaz-Schatz stent implantation. (C) 1998 Wiley-Liss, Inc.