MOLECULAR RECOGNITION ON FUNCTIONALIZED SELF-ASSEMBLED MONOLAYERS OF ALKANETHIOLS ON GOLD

A system for probing molecular recognition events at organic interface s using fluorescent receptors is described. Receptors formed from the bis(2,6-diaminopyridine) amide of isophthalic acid are incorporated in mixed,self-assembled monolayers (SAMs) of alkanethiols on gold and sh own to interact with barbituric acid derivatives from solution. Indivi dual parameters that affect the ability of receptors on surfaces to re cognize ligands from solution along with varieties of solvents for lig and solutions have been examined.