Background: Exercise performance data of numerous altitude research st
udies and competitive sporting events of the last four decades are rev
iewed. Methods: The primary focus is on the wide interindividual varia
tion associated with maximal and submaximal exercise performance that
occurs at different altitudes and for different periods of time at alt
itude. Results: Fitness level, pre-exposure resident altitude, gender,
and du ration of altitude exposure are qualitatively assessed to dete
rmine their contribution to the overall variability. Of these, pre-alt
itude exposure fitness level difference contributes the most variabili
ty and gender difference contributes the least. It is also determined
that beginning at an altitude of 580 m, maximal aerobic power (V) over
dot O(2)max reduced and does not improve with extended exposure as lo
ng as the individual's level of fitness level is not altered significa
ntly by increases in activity, exercise training or by altitude-induce
d physical deterioration. Submaximal exercise performance is also impa
ired at altitude. Conclusion: By assessing the performance of elite at
hletes, who are performing at an ''all-out'' effort in precisely timed
events for which they are trained, it is determined that: a) the magn
itude of submaximal exercise impairment is proportional to both the el
evation and exercise duration at a given altitude; and b) submaximal e
xercise performance at altitude can Improve with continued exposure wi
thout an increase in (V) over dot O(2)max. Muscle strength, maximal mu
scle power, and anaerobic performance at altitude are not affected as
long as muscle mass is maintained. In addition, performance is not imp
aired in athletic activities that have a minimal aerobic component and
can be performed at high velocity (e.g., sprints).