Background and Purpose-Three-dimensional (3-D) vascular ultrasound can
be expected to improve qualitative evaluation of vessel pathology and
to provide quantitative data on vascular morphology and function. The
objective of this study was to develop an ultrafast 3-D vascular syst
em and to validate its performance for quantitation of atherosclerosis
and assessment of regional arterial distensibility. Methods-The quant
itative analysis of focal atherosclerotic lesions was validated in vit
ro on 27 phantoms of fibroadipous plaques of known volume (range, 100
to 600 mm(3)). In vivo reproducibility of plaque volume measurement wa
s tested in 33 patients who had a total of 47 predominantly fibroadipo
us carotid plaques. Distensibility assessment was validated indirectly
through the evaluation of age-related changes in distensibility of co
mmon carotid artery in healthy and hypertensive subjects (25 men in ea
ch group). Results-The volume of plaque phantoms measured from the 3-D
data set showed a very close correlation with the true volume (r=0.99
; y=0.96x+12.38; P<0.01), with the mean difference between the 2 measu
rements being -3.12+/-15.1 mm3. High reproducibility was found for mea
surement of carotid plaque volume in vivo: the mean difference between
measurements from 2 observers for the same data set was 0.60+/-11.2 m
m(3). Indexes of arterial distensibility decreased with age in healthy
population, whereas this relationship was lost in hypertensive subjec
ts. Conclusions-Ultrafast 3-D ultrasound imaging of carotid artery dem
onstrates good accuracy and reproducibility for atherosclerotic plaque
volume measurements, The system also allows the study of age-related
degenerative vascular changes.