POLYMER DRUGS AND POLYMERIC DRUGS - IX - SYNTHESIS AND 5-FLUOROURACILRELEASE PROFILES OF BIODEGRADABLE POLYMERIC PRODRUGS POLY(ALPHA-HYDROXYMETHYL-5-FLUOROURACIL-GLUTAMATE)

Authors
KISHIDA A GOTO H MURAKAMI K KAKINOKI K AKASHI M ENDO T
Citation
A. Kishida et al., POLYMER DRUGS AND POLYMERIC DRUGS - IX - SYNTHESIS AND 5-FLUOROURACILRELEASE PROFILES OF BIODEGRADABLE POLYMERIC PRODRUGS POLY(ALPHA-HYDROXYMETHYL-5-FLUOROURACIL-GLUTAMATE), Journal of bioactive and compatible polymers, 13(3), 1998, pp. 222-233
Citations number
13
Categorie Soggetti
Polymer Sciences","Biothechnology & Applied Migrobiology","Materials Science, Biomaterials
Journal title
Journal of bioactive and compatible polymers → ACNP
ISSN journal
08839115
Volume
13
Issue
3
Year of publication
1998
Pages
222 - 233
Database
ISI
SICI code
0883-9115(1998)13:3<222:PDAPD->2.0.ZU;2-8
Abstract
A conjugate of poly(gamma-glutamic acid)(gamma-PGA) with 5-fluorouraci l (5-FU) ( ly(alpha-hydroxymethyl-5-fluorouracil-glutamate)), gamma-PF UG, was prepared as a polymeric prodrug matrix. The release of 5-FU an d the degradation behavior of gamma-PFUG, which is soluble in polar or ganic solvents were studied. gamma-PFUG films were prepared by casting from DMF. The gamma-PFUG matrix degraded in 7 days and incorporated 5 -FU was released in 3 days. 5-FU release was accelerated by mixing fre e 5-FU into gamma-PFUG. Here, gamma-PFUG functioned as a hydrophobic d egradable matrix. Analogous with gamma-PFUG, gamma-PGA conjugated with a drug may be useful as a biodegradable polymeric prodrug.