ANTIMICROBIAL ACTIVITY OF SOME 1,2-BENZISOTHIAZOLES HAVING A BENZENESULFONAMIDE MOIETY

Some sulfonamide and sulfonylurea derivatives of unsubstituted and 5-m ethylsubstituted 1,2-benzisothiazole were studied in vitro for their a ntimicrobial properties against bacteria and fungi. Compounds 7 and 8 exhibited good antibacterial activity against Gram positive bacteria. A strong synergism was observed when their growth-inhibitory effect wa s assayed in combination with trimethoprim by using Bacillus subtilis and Staphylococcus aureus as test microorganisms. The antimycotic acti on of benzenesulfonylurea derivative 9 was very marked for Madurella m ycetomatis and dermatophytes Epidermophyton floccosum, Microsporum gyp seum and Trichophyton spp.. Structure-activity relations are discussed .