N. Jagarinec et al., PEDIATRIC REFERENCE INTERVALS FOR 34 BIOCHEMICAL ANALYTES IN URBAN SCHOOL-CHILDREN AND ADOLESCENTS, CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 36(5), 1998, pp. 327-337
Concentrations of 34 biochemical constituents of sera were determined
on 998 randomly selected urban school children and adolescents aged 8-
18 years from Zagreb, Croatia. Reference intervals were obtained by us
ing non-parametric methods to estimate 2.5 and 97.5 percentiles of dis
tribution as upper and lower normal reference intervals, according to
the IFCC recommendations. These were compared to reference intervals i
n the healthy adult population, aged 20-30 years from the same geograp
hical area. Serum glucose, potassium, sodium, chloride, magnesium, iro
n, zinc, total serum proteins and electrophoretic fractions, and amyla
se, did not show age or sex differences; total serum bilirubin, total
calcium, phosphate, high density lipoprotein cholesterol, total iron b
inding capacity, unsaturated iron binding capacity, copper, aspartate
aminotransferase, alkaline phosphatase, cholinesterase, creatine kinas
e, and lactate dehydrogenase had higher reference intervals than the a
dult population. Urea, creatinine, urate, alanine aminotransferase, ga
mma-glutamyltransferase, total cholesterol and low density lipoprotein
-cholesterol, and triglycerides had lower reference intervals than the
adult population.