Ka. Sepkowitz et al., POSTEXPOSURE PROPHYLAXIS FOR HUMAN-IMMUNODEFICIENCY-VIRUS - FREQUENCYOF INITIATION AND COMPLETION OF NEWLY RECOMMENDED REGIMEN, Infection control and hospital epidemiology, 19(7), 1998, pp. 506-508
Recent evidence demonstrating the efficacy of zidovudine, as well as e
xperience with protease inhibitors, led to revision of recommendations
for occupational exposures to human immunodeficiency virus-infected b
lood. At our hospital, this resulted in significant increases in rates
of reported exposures and prophylaxis initiation. Among 10 healthcare
workers given three-drug, protease-inhibitor-containing regimens, fiv
e completed 4 weeks, two completed 4 weeks of two drugs, and three sto
pped due to intolerance. Three workers missed work due to side effects
.