COMBINATORIAL SYNTHESIS AND SCREENING OF A CHEMICAL LIBRARY OF 1,4-DIHYDROPYRIDINE CALCIUM-CHANNEL BLOCKERS

Authors
GORDEEV MF PATEL DV ENGLAND BP JONNALAGADDA S COMBS JD GORDON EM
Citation
Mf. Gordeev et al., COMBINATORIAL SYNTHESIS AND SCREENING OF A CHEMICAL LIBRARY OF 1,4-DIHYDROPYRIDINE CALCIUM-CHANNEL BLOCKERS, Bioorganic & medicinal chemistry, 6(7), 1998, pp. 883-889
Citations number
57
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
7
Year of publication
1998
Pages
883 - 889
Database
ISI
SICI code
0968-0896(1998)6:7<883:CSASOA>2.0.ZU;2-C
Abstract
Solid-phase synthesis of a 300-member pharmacophore library of 1,4-dih ydropyridines from keto ester, diketone and aldehyde building blocks o n a cleavable amine polymeric support is described. Screening and seri al deconvolution of the combinatorial library has resulted in identifi cation of known and new potent calcium channel blockers. (C) 1998 Else vier Science Ltd. All rights reserved.