MODIFICATIONS OF THE ALPHA,BETA-DOUBLE BOND IN CHALCONES ONLY MARGINALLY AFFECT THE ANTIPROTOZOAL ACTIVITIES

Authors
NIELSEN SF KHARAZMI A CHRISTENSEN SB
Citation
Sf. Nielsen et al., MODIFICATIONS OF THE ALPHA,BETA-DOUBLE BOND IN CHALCONES ONLY MARGINALLY AFFECT THE ANTIPROTOZOAL ACTIVITIES, Bioorganic & medicinal chemistry, 6(7), 1998, pp. 937-945
Citations number
50
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
7
Year of publication
1998
Pages
937 - 945
Database
ISI
SICI code
0968-0896(1998)6:7<937:MOTABI>2.0.ZU;2-B
Abstract
Methods for selective alkylation of chalcones in the alpha- or beta-po sition and for selective reduction of the alpha,beta-double bond have been developed. The antiparasitic potencies of the alpha,beta-double b ond modified chalcones only differ marginally from the potencies of th e parent chalcones indicating that the propenone residue only function s as a spacer between the two benzene rings, which are the true pharma cophore. (C) 1998 Elsevier Science Ltd. All rights reserved.