NOVEL DITHIOCARBAMATE CARBAPENEMS WITH ANTI-MRSA ACTIVITY

Authors
OHTAKE N IMAMURA H JONA H KIYONAGA H SHIMIZU A MORIYA M SATO H NAKANO M USHIJIMA R NAKAGAWA S
Citation
N. Ohtake et al., NOVEL DITHIOCARBAMATE CARBAPENEMS WITH ANTI-MRSA ACTIVITY, Bioorganic & medicinal chemistry, 6(7), 1998, pp. 1089-1101
Citations number
19
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
7
Year of publication
1998
Pages
1089 - 1101
Database
ISI
SICI code
0968-0896(1998)6:7<1089:NDCWAA>2.0.ZU;2-O
Abstract
A new series of 1 beta-methyl carbapenems, in which a disubstituted-am inothiocarbonylthio moiety was attached to the C-2 position of the car bapenem nucleus, were prepared and evaluated for anti-MRSA activity. T hese derivatives showed good in vitro antibacterial activity against h igh-level MRSA, and the finding of good affinity for PBP-2' supported these results. Some of the compounds having favorable protein-binding affinity showed excellent in vivo anti-MRSA activity. (C) 1998 Elsevie r Science Ltd. All rights reserved.