PHOTOAFFINITY-LABELING OF PKC ISOZYMES BY PHORBOL ESTER DERIVATIVES

Authors
UOTSU K SODEOKA M SHIBASAKI M
Citation
K. Uotsu et al., PHOTOAFFINITY-LABELING OF PKC ISOZYMES BY PHORBOL ESTER DERIVATIVES, Bioorganic & medicinal chemistry, 6(7), 1998, pp. 1117-1126
Citations number
39
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
7
Year of publication
1998
Pages
1117 - 1126
Database
ISI
SICI code
0968-0896(1998)6:7<1117:POPIBP>2.0.ZU;2-V
Abstract
Photoaffinity probes PPDA and PPTD, which have diazoacetyl and trifluo rodiazopropionyl group at C-13 position in phorbol, respectively, were synthesized. Photoaffinity labeling of protein kinase C isozymes by b oth the probes resulted in specific cross-linking. (C) 1998 Elsevier S cience Ltd. All rights reserved.