REGIONAL DIFFERENCES IN THE EFFECTS OF GLUTAMATE UPTAKE INHIBITOR L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID ON EXTRACELLULAR AMINO-ACIDS AND DOPAMINE IN RAT-BRAIN - AN IN-VIVO MICRODIALYSIS STUDY

The effects of the glutamate transporter inhibitor, trans-PDC, on extr acellular amino acids, were investigated in the frontal cortex, striat um, hippocampus and cerebellum of rats using tn vivo microdialysis. Tr ans-PDC infusion (0.1, 1, 10 mM) dose dependently increased Glu and As p levels, and these increases in the cerebellum were smaller than thos e in other brain regions. A small but significant dose dependent incre ase was observed for Gly and Tau. However, high extracellular Glu indu ced by trans-PDC was not sufficient to increase extracellular DA in th e striatum and frontal cortex. GEN PHARMAC 31;3:399-404, 1998. (C) 199 8 Elsevier Science Inc.