Objective: To study the effect of an educational intervention on the m
anagement of hospitalized infants with bronchiolitis. Design: Sequenti
al, prospective cohort study. Setting: A 235-bed children's hospital w
ith nearly all private rooms. Patients: Consecutively admitted, previo
usly healthy children younger than 24 months with symptoms of bronchio
litis. The first cohort was enrolled between January 1 and January 21,
1996; the second cohort between January 29 and February 18, 1996, fol
lowing a 1-week intervention period; the third (followup) cohort betwe
en December 1996 and February 1997. Intervention: Educational program
and practice guidelines aimed at appropriate utilization of diagnostic
tests, decreased antibiotic and bronchodilator use, increased complia
nce with isolation, decreased length of stay, and maintenance of quali
ty care. Main Outcome Measures: Utilization of respiratory syncytial v
irus (RSV) enzyme immunoassay, initiation and duration of parenteral a
ntibiotic therapy, number of nebulized bronchodilator treatments, isol
ation orders, length of stay, and readmission rate. Results: A total o
f 90 patients were studied preintervention, 63 postintervention, and 9
0 during the follow-up period. The groups were comparable in demograph
ic and clinical features. No patient had a documented serious bacteria
l infection; however, almost half in each group received parenteral an
tibiotics, despite recommendations against this. Immediately postinter
vention, children with positive RSV test results received antibiotics
on fewer days than other children (median 0.6 vs 2.4 days; P = .004),s
uggesting that physicians stopped treatment with antibiotics once a vi
ral diagnosis was confirmed. This effect did not persist into the foll
ow-up period. Viral testing was reduced and isolation orders increased
. Use of bronchodilators was reduced from 91% preintervention to 80% d
uring the follow-up period (P = .046), and the median number of treatm
ents was reduced from 15.0 to 10.0 (P = .005). There was no change in
length of stay, which was 2 to 3 days, or in readmission rate, which w
as 1% to 4%. Conclusion: Educational efforts centered around practice
guidelines can improve some aspects of the treatment of patients hospi
talized with bronchiolitis.