GOODPASTURES-SYNDROME ASSOCIATED WITH MULTIPLE-SCLEROSIS

Multiple sclerosis (MS) has been reported to occur in association with other autoimmune diseases. Here we report the case of a woman with pr imary progressive MS who developed and died of Goodpasture's syndrome associated with anti-glomerular basement membrane antibodies. Of inter est she had the human leukocyte antigen haplotype (DRB11501-DQA1*0102 -DQB10602) most frequently associated with these two diseases; howeve r, it is likely that other genes, particularly those involved with imm unoregulation, also contributed to her susceptibility to these disease s. The association of MS and autoimmune renal disease may be more comm on than currently recognized.