CHARACTERIZATION OF TEMPERATURE RISE OF THE BRAIN AND THE RECTUM FOLLOWING INTRACEREBROVENTRICULAR ADMINISTRATION OF PHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONATE AND KAINATE IN RATS

Intracerebroventricular administration of pha-amino-3-hydroxy-5-methyl -4-isoxazolepropionate (AMPA) or kainate caused a rise of the temperat ure of the brain and the rectum in urethane-anesthetized rats. An AMPA -kainate receptor antagonist, 6,7-dinitroquinoxaline-2,3-dione (DNQX), significantly suppressed the AMPA- and kainate-induced rises of brain and rectal temperatures. An N-methyl-D-aspartate receptor antagonist, MK-801, also suppressed the rises of the brain and rectal temperature s induced by AMPA or kainate, but the profiles of the suppressive effe cts of MK-SOL were different between rats treated with AMPA and kainat e. An antipyretic agent, indomethacin, completely suppressed the AMPA- induced rises of brain and rectal temperatures. Although indomethacin completely suppressed the kainate-induced rise of the rectal temperatu re as well, the brain temperature was still raised. These findings sug gest that distinct mechanisms may be involved in the temperature rise of the brain and the rectum mediated through AMPA and kainate receptor stimulation. (C) 1998 Elsevier Science B.V. All rights reserved.