CD2-TRIPHOSPHATE IN BOVINE CHROMAFFIN CELLS( AND CO2+ AT MICROMOLAR CONCENTRATIONS MOBILIZE INTRACELLULAR CA2+ VIA THE GENERATION OF INOSITOL 1,4,5)

Authors
YAMAGAMI K NISHIMURA S SORIMACHI M
Citation
K. Yamagami et al., CD2-TRIPHOSPHATE IN BOVINE CHROMAFFIN CELLS( AND CO2+ AT MICROMOLAR CONCENTRATIONS MOBILIZE INTRACELLULAR CA2+ VIA THE GENERATION OF INOSITOL 1,4,5), Brain research, 798(1-2), 1998, pp. 316-319
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
798
Issue
1-2
Year of publication
1998
Pages
316 - 319
Database
ISI
SICI code
0006-8993(1998)798:1-2<316:CIBCCA>2.0.ZU;2-B
Abstract
To understand the mechanisms underlying the Cd2+- and Co2+-induced int racellular Ca2+ mobilization, we measured the levels of inositol phosp hates using bovine chromaffin cells. Studies using HPLC indicated that Cd2+, Co2+ and methacholine significantly increased the generation of 1,4,5-IP3. The results suggest that Cd2+ and Co2+ mobilize Ca2+ from IP3-sensitive Ca2+ stores, possibly through the presumptive Cd2+ recep tor. (C) 1998 Elsevier Science B.V. All rights reserved.