NEUROPATHY ASSOCIATED WITH ANGIOIMMUNOBLASTIC LYMPHADENOPATHY-LIKE T-CELL LYMPHOMA

A 75-year-old woman was admitted because of pain and numbness in the e xtremities and trunk, She subsequently suffered from lymphadenopathy a nd spiky fever. The immunohistochemical analysis of the biopsied lymph nodes and sural nerve and electrophysiological examination supported a diagnosis of angioimmunoblastic lymphadenopathy-like T cell lymphoma with polyneuropathy, The infiltrating lymphoma cells of the sural ner ve and lymph node shared the same phenotype (CD45RO, CD3, CD30 positiv e). An increased expression of HLA-DR antigen was observed in endothel ial and Schwann cells. Chemotherapy with CHOP-Bleomycin markedly relie ved her pain. These findings suggest that a direct lymphocytic infiltr ation in the nerve may be associated with neuropathy in this case.