THE EFFECT OF COLLAGEN, INTERLEUKIN-1-ALPHA AND GLYCOSAMINOGLYCAN ON THE NEOVASCULARIZATION OF CENTRAL-NERVOUS-SYSTEM

Neovascularization, the development of a new microvasculature, has an important role in physiological and pathological processes. The vascul ar changes in the Drain can be easily detected because the proliferati on of endothelial cells in its vascular structure is quite small, and so constitutes a good model for neovascularization studies. In the pre sent investigation, to induce intracerebral neovascularization, we imp lanted collagen, Interleukin-1alpha (IL-1 alpha) and glicosaminoglycan into the brain of pigs, in order to test the hypothesis that IL-1 alp ha, collagen and glicosaminoglycan play a pivotal role in the process of neovascularization. Both pure collagen and collagen combined with I L-1 alpha induced neovascularization according to light-electron micro scopic findings and values oi enzymes' activities. In particular, coll agen combined with IL-la synergically affected the increase of neovasc ularization. However, glicosaminoglycan did not affect it significantl y Although the results of this study provided us with some interesting data indicating the beneficial effects of collagen combined with IL-1 alpha on neovascularization, further studies should be done to study the short term effect of these biochemical substances.