NEUROPHARMACOLOGICAL ACTIVITY OF SOLANUM-NIGRUM FRUIT

The ethanol extract of the fruit of Solanum nigrum L. (Solanaceae) was studied for its neuropharmacological properties on experimental anima ls. On intraperitoneal injection, the extract significantly prolonged pentobarbital-induced sleeping time, produced alteration in the genera l behavior pattern, reduced exploratory behavior pattern, suppressed t he aggressive behavior, affected locomotor activity and reduced sponta neous motility. The observations suggest that the fruit of S. nigrum p ossesses potential CNS-depressant action. (C) 1998 Elsevier Science Ir eland Ltd. All rights reserved.