IDENTIFICATION OF NOVEL MUTATION PATTERNS IN THE PARC GENE OF CIPROFLOXACIN-RESISTANT ISOLATES OF NEISSERIA-GONORRHOEAE

Of 65 ciprofloxacin-resistant, clinical isolates of Neisseria gonorrho eae, 5 isolates exhibited ParC mutations previously undescribed in the gonococcus. For isolates containing two ParC mutations (the Ser-87--> Ile and Glu-91-->Gly mutations and the Gly-85-->Cys and Arg116-->Leu m utations) the MICs of ciprofloxacin (8.0 to 64.0 mu g/ml) were higher than those for the isolate containing the single ParC mutation (Arg-11 6-->Leu; MIC, 1.0 mu g/ml).