INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION IN SCID-HU THY LIV MICE BY THE G-QUARTET-FORMING OLIGONUCLEOTIDE, ISIS-5320/

Authors
STODDART CA RABIN L HINCENBERGS M MORENO ME LINQUISTSTEPPS V LEEDS JM TRUONG LA WYATT JR ECKER DJ MCCUNE JM
Citation
Ca. Stoddart et al., INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION IN SCID-HU THY LIV MICE BY THE G-QUARTET-FORMING OLIGONUCLEOTIDE, ISIS-5320/, Antimicrobial agents and chemotherapy, 42(8), 1998, pp. 2113-2115
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
8
Year of publication
1998
Pages
2113 - 2115
Database
ISI
SICI code
0066-4804(1998)42:8<2113:IOHTII>2.0.ZU;2-9
Abstract
Viral replication was inhibited in a dose-dependent manner after admin istration of the phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) to human immunodeficiency virus type 1 (HIV-1)-infected SCID-hu Thy/L iv mice. Potent in vivo antiviral activity was observed against the T- cell-tropic molecular clone NL4-3; the agent was found to have weak ac tivity against one primary HIV-1 isolate, and the agent was inactive a gainst a second primary isolate.