TOPOISOMERASE MUTATIONS IN TROVAFLOXACIN-RESISTANT STAPHYLOCOCCUS-AUREUS

Authors
FITZGIBBON JE JOHN JF DELUCIA JL DUBIN DT
Citation
Je. Fitzgibbon et al., TOPOISOMERASE MUTATIONS IN TROVAFLOXACIN-RESISTANT STAPHYLOCOCCUS-AUREUS, Antimicrobial agents and chemotherapy, 42(8), 1998, pp. 2122-2124
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
8
Year of publication
1998
Pages
2122 - 2124
Database
ISI
SICI code
0066-4804(1998)42:8<2122:TMITS>2.0.ZU;2-D
Abstract
A total of 201 Staphylococcus aureus isolates were surveyed for suscep tibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resista nt isolates, 89% were ciprofloxacin resistant and 6% were also trovafl oxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resistance mutations in DNA topoisomerase genes, includi ng two mutations in the A subunit (encoded by grlA) of topoisomerase I V.