SYNTHESIS OF UNSYMMETRIC CYCLIC UREA DIOLS, A NOVEL CLASS OF HIV PROTEASE INHIBITORS

Authors
STONE BRP HARRIS GD CANN RO SMYSER TE CONFALONE PN
Citation
Brp. Stone et al., SYNTHESIS OF UNSYMMETRIC CYCLIC UREA DIOLS, A NOVEL CLASS OF HIV PROTEASE INHIBITORS, Tetrahedron letters, 39(34), 1998, pp. 6127-6130
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
34
Year of publication
1998
Pages
6127 - 6130
Database
ISI
SICI code
0040-4039(1998)39:34<6127:SOUCUD>2.0.ZU;2-1
Abstract
Unsymmetric cyclic urea diols of general structure 1 can be prepared e ither via an isourea derived from the symmetric diamine 2 or by the se lective removal of a benzyl group from certain symmetric cyclic ureas 8, employing dissolving metal reduction. (C) 1998 The DuPont Merck Pha rmaceutical Company. Published by Elsevier Science Ltd. All rights res erved.