A NOVEL CARBOXY-FUNCTIONALIZED PHOTOCLEAVABLE DINUCLEOTIDE ANALOG FORTHE SELECTION OF RNA CATALYSTS

Authors
HAUSCH F JASCHKE A
Citation
F. Hausch et A. Jaschke, A NOVEL CARBOXY-FUNCTIONALIZED PHOTOCLEAVABLE DINUCLEOTIDE ANALOG FORTHE SELECTION OF RNA CATALYSTS, Tetrahedron letters, 39(34), 1998, pp. 6157-6158
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
34
Year of publication
1998
Pages
6157 - 6158
Database
ISI
SICI code
0040-4039(1998)39:34<6157:ANCPDA>2.0.ZU;2-I
Abstract
A new multifunctional dinucleotide analog is synthesized for the appli cation in in vitro selection experiments with linker-coupled reactants . For this purpose it contains a 5'-pCC ligation site, three flexible hexaethylene glycol spacers, a photocleavable o-nitrobenzyl unit and a 3'-terminal carboxy-function which can be derivatized with potential reactants as demonstrated with three model compounds. (C) 1998 Elsevie r Science Ltd. All rights reserved.