ELECTROREDUCTIVE COUPLING OF ALIPHATIC AMIDES - A USEFUL METHOD FOR THE SYNTHESIS OF ALPHA-AMINO KETONES

Authors
KASHIMURA S ISHIFUNE M MURAI Y MURASE H SHIMOMURA M SHONO T
Citation
S. Kashimura et al., ELECTROREDUCTIVE COUPLING OF ALIPHATIC AMIDES - A USEFUL METHOD FOR THE SYNTHESIS OF ALPHA-AMINO KETONES, Tetrahedron letters, 39(34), 1998, pp. 6199-6202
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
34
Year of publication
1998
Pages
6199 - 6202
Database
ISI
SICI code
0040-4039(1998)39:34<6199:ECOAA->2.0.ZU;2-S
Abstract
Electroreduction of aliphatic amides (RCONMe2) with Mg electrode in th e presence of chlorotrimethylsilane (TMSCl) has been found to give the coupling products [R(TMSO)C=C(NMe2)R] and hydrolysis of the products affords the corresponding alpha-amino ketones [RCOCH(NMe2)R] in excell ent yields. (C) 1998 Elsevier Science Ltd. All rights reserved.