TESTING OF SOS INDUCTION OF ARTIFICIAL POLYCYCLIC MUSK FRAGRANCES IN ESCHERICHIA-COLI PQ37 (SOS CHROMOTEST)

Synthetic fragrances are widespread in the environment. Residues were found in animals, human tissues and breast milk. Therefore, six artifi cial polycyclic musk fragrances-Galaxolide, Tonalide, Celestolide, Pha ntolide, Cashmeran and Traseolide-were tested for SOS induction using the Escherichia coli PQ37 genotoxicity assay (SOS chromotest) in the p resence (+S9) and absence (-S9) of an exogenous metabolizing system. A ll compounds tested exhibited no SOS inducing potency with the SOS chr omotest. These results could be rated as one indicator of the biologic al inactivity of this group of compounds with respect to genotoxicity. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.