A. Ainaoui et Jm. Vergnaud, MODELING THE PLASMA DRUG LEVEL WITH ORAL CONTROLLED-RELEASE DOSAGE FORMS WITH LIPIDIC GELUCIRE, International journal of pharmaceutics, 169(2), 1998, pp. 155-162
The plasma drug level is evaluated in the case of oral dosage forms wi
th prolonged release when the matrix is made of lipidic Gelucire. From
in vitro studies, the process of drug release follows a typical patte
rn: the liquid dissolves the drug in contact with it and thus, enters
the dosage form, enabling the drug to diffuse out of the dosage form t
hrough the liquid located in it. The diffusivity of the drug increases
with the concentration of the liquid in an exponential way. The kinet
ics of drug release out of the dosage forms fit the experimental resul
ts obtained with in vitro experiments perfectly. The plasma drug level
is obtained with aspirin as the drug, by using a numerical model taki
ng into account the kinetics of release of the drug out of the dosage
form and the pharmacokinetic parameters. The effect of the dimensions
of the dosage forms on the plasma drug level is considered. (C) 1998 E
lsevier Science B.V. All rights reserved.