QUANTITATION OF REGIONAL CEREBRAL BLOOD-FLOW INCREASES IN PREFRONTAL CORTEX DURING A WORKING-MEMORY TASK - A STEADY-STATE ARTERIAL SPIN-TAGGING STUDY

Authors
YE FQ SMITH AM MATTAY VS RUTTIMANN UE FRANK JA WEINBERGER DR MCLAUGHLIN AC
Citation
Fq. Ye et al., QUANTITATION OF REGIONAL CEREBRAL BLOOD-FLOW INCREASES IN PREFRONTAL CORTEX DURING A WORKING-MEMORY TASK - A STEADY-STATE ARTERIAL SPIN-TAGGING STUDY, NeuroImage (Orlando, Fla. Print), 8(1), 1998, pp. 44-49
Citations number
33
Categorie Soggetti
Neurosciences,"Radiology,Nuclear Medicine & Medical Imaging
Journal title
NeuroImage (Orlando, Fla. Print) → ACNP
ISSN journal
10538119
Volume
8
Issue
1
Year of publication
1998
Pages
44 - 49
Database
ISI
SICI code
1053-8119(1998)8:1<44:QORCBI>2.0.ZU;2-C
Abstract
Steady-state arterial spin-tagging MRI approaches were used to quantit ate regional cerebral blood flow increases in prefrontal cortex during a working memory (''two-back'') task in six normal subjects. Statisti cally significant increases in cerebral blood flow in prefrontal corte x were observed in all six subjects: the average increase in cerebral blood flow in activated prefrontal cortex regions was 22 +/- 5 cc/100 g/min (23 +/- 7%). The results demonstrate that spin-tagging approache s can be used to follow focal activation in prefrontal cortex during c ognitive tasks. (C) 1998 Academic Press.