POSSIBLE INVOLVEMENT OF LIPID-PEROXIDATION IN THE INHIBITION OF TYPE-I IODOTHYRONINE 5'-MONODEIODINASE ACTIVITY BY LEAD IN CHICKEN LIVER

Authors
CHAURASIA SS GUPTA P MAITI PK KAR A
Citation
Ss. Chaurasia et al., POSSIBLE INVOLVEMENT OF LIPID-PEROXIDATION IN THE INHIBITION OF TYPE-I IODOTHYRONINE 5'-MONODEIODINASE ACTIVITY BY LEAD IN CHICKEN LIVER, Journal of applied toxicology, 18(4), 1998, pp. 299-300
Citations number
9
Categorie Soggetti
Toxicology
Journal title
Journal of applied toxicology → ACNP
ISSN journal
0260437X
Volume
18
Issue
4
Year of publication
1998
Pages
299 - 300
Database
ISI
SICI code
0260-437X(1998)18:4<299:PIOLIT>2.0.ZU;2-6
Abstract
The possible involvement of lipid peroxidation (LPO) in the lead-induc ed inhibition of type I iodothyronine 5'-monodeiodinase activity (5'-D ) has been worked out in chicken liver. Lead nitrate (1.5 mg per bird per day) for 30 days increased the lipid peroxidative process with a c oncomitant decrease in 5'-D activity in chicken liver. Also, a signifi cant decrease in serum triiodothyronine (T-3) concentration and an inc rease in serum thyroxine (T-4) concentration were observed. The data s uggest that lead-induced inhibition of type I 5'-D activity in chicken liver is mediated through the lipid peroxidative process. (C) 1998 Jo hn Wiley & Sons, Ltd.