Oral retinoids are molecules derived from vitamin A that represent one
of the most important steps forward in dermatologic therapeutics in t
he present century The treatment of acne, severe psoriasis, and severe
disorders of keratinization, prevalent diseases in children and adole
scents, have radically changed since the advent of oral retinoids. Lik
e most highly-effective medications, oral retinoids also have importan
t untoward effects. Specialists, and in particular, dermatologists and
pediatricians should be prepared to maneuver the delicate balance bet
ween therapeutic efficacy and side effects in order to give the pediat
ric patient the maximum benefit with the lowest possible risk.