IN-VIVO CARDIOTONIC ACTIVITY OF PYRIDYLMETHYLENE-2-INDOLINONES

Authors
ANDREANI A LOCATELLI A MORIGI R LEONI A BOSSA R CHIERICOZZI M GALATULAS I
Citation
A. Andreani et al., IN-VIVO CARDIOTONIC ACTIVITY OF PYRIDYLMETHYLENE-2-INDOLINONES, Arzneimittel-Forschung, 48(7), 1998, pp. 727-729
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
48
Issue
7
Year of publication
1998
Pages
727 - 729
Database
ISI
SICI code
0004-4172(1998)48:7<727:ICAOP>2.0.ZU;2-Z
Abstract
The synthesis of 5-chloro-3-pyridylmethylene-2-indolinone is reported. This compound was subjected to an in vivo cardiotonic assay with 10 a nalogs whose synthesis and in vitro cardiotonic activity were previous ly reported. All the compounds tested (except the 5-hydroxyindole deri vative) showed significant positive inotropic activity. The 3-pyridyl derivative without substituents at the indole system was the most acti ve of the whole series.