CELL-MEDIATED-IMMUNITY IN ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS

Authors
KNUTSEN AP CHAUHAN B SLAVIN RG
Citation
Ap. Knutsen et al., CELL-MEDIATED-IMMUNITY IN ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS, Immunology and allergy clinics of North America, 18(3), 1998, pp. 575
Citations number
140
Categorie Soggetti
Allergy,Immunology
Journal title
Immunology and allergy clinics of North America → ACNP
ISSN journal
08898561
Volume
18
Issue
3
Year of publication
1998
Database
ISI
SICI code
0889-8561(1998)18:3<575:CIABA>2.0.ZU;2-4
Abstract
The pathogenesis of ABPA is characterized by a heightened Th2 CD4+ aut ocrine late-phase allergic inflammatory response to A. fumigatus aller gens in the bronchial airway of patients with atopic asthma and patien ts with CF. in addition, T-cell responses to A. fumigatus allergens ar e HLA-DR2 and DR5 and TCR-V restricted in ABPA. The underlying suscept ibility to develop ABPA versus an asthmatic allergic response to A. fu migatus allergens, however, is not understood.