SUCCESSFUL TREATMENT WITH NEDAPLATIN IN PATIENTS WITH OVARIAN-CANCER THAT RECURRED AFTER PLATINUM-CONTAINING CHEMOTHERAPY - REPORT OF 2 CASES

We report the successful treatment with nedaplatin of hive cases of ov arian cancer that recurred after platinum-containing chemotherapy, A 5 2-year-old woman presented in June 1994 with massive accumulation of a scitic fluid. Pathological diagnosis of the specimen obtained at surge ry in July 1994 was serous papillary adenocarcinoma of the ovary. In S eptember 1995, approximately seven months after the completion of six cycles of CAP chemotherapy (cyclophosphamide, adriamycin and cisplatin um), she was referred to our hospital because of massive accumulation of ascitic fluid. The carbohydrate antigen 125 (CA-125) value was 485 U/ml, Cytologic study of her ascitic fluid was positive for adenocarci noma cells. She did not respond to intravenous irinotecan and two cycl es of intraperitoneal cisplatin. Nedaplatin 100 mg/m(2) was administer ed. Complete response was achieved in September 1996 and continued for four months with a total of seven cycles of nedaplatin. The second ca se was a 60-year-old woman who was admitted to our hospital in Decembe r 1994 because of ascitic fluid. Diagnosis of ovarian cancer was based on an elevated level of CA-125 (1380 U/ml), Treatment with CAP and CC (cyclophosphamide and carboplatin) maintained a partial response for seven months. In August 1996, her disease progressed, although she was receiving CC therapy. Nedaplatin 100 mg/m(2) was administered. Partia l response was achieved again in November 1996 and continued for four months, with a total of five cycles of nedaplatin, In the light of our experience, treatment with nedaplatin in a patient with recurrent ova rian cancer might be worthwhile as palliative chemotherapy.