STUDIES ON THE ALLYL PROTECTION OF HYDROXYL GROUP IN NUCLEOSIDES

Authors
ZHOU Y ZHANG LR ZHANG LH
Citation
Y. Zhou et al., STUDIES ON THE ALLYL PROTECTION OF HYDROXYL GROUP IN NUCLEOSIDES, Gaodeng xuexiao huaxue xuebao, 19(5), 1998, pp. 728-731
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Gaodeng xuexiao huaxue xuebao → ACNP
ISSN journal
02510790
Volume
19
Issue
5
Year of publication
1998
Pages
728 - 731
Database
ISI
SICI code
0251-0790(1998)19:5<728:SOTAPO>2.0.ZU;2-W
Abstract
The possibility of allyl as the protection group of the hydroxyls in n ucleosides was studied. Allyl bromide can react with thymidine and ade nosine in the presence of NaOH to give O-allyl protected nucleosides i n good yield. PdCl2 can be used as a reagent for the deprotection. It was found that PdCl2 can selectively deprotect the p-methoxytrityl, di -p-methoxytrityl or both of the p-methoxytrityl, di-p-methoxytrityl an d allyl group.